Scientists reveal how 35B5 antibody neutralizes SARS-CoV-2 Omicron
1
2522728
/english/2022/0422/c65147a2522728/page.psp
2022-04-22
static/picture/b8cf49c7-b97f-4f4c-9257-0fcea3ee41e1_s.jpg
static/picture/b8cf49c7-b97f-4f4c-9257-0fcea3ee41e1.jpg
Since November 2021, the SARS-CoV-2 Omicron has spread expeditiously all over the world and gradually superseded the previous attention-capturing the SARS-CoV-2 variants of concern (VOCs). The Omicron variant harbors more than 30 mutations in the spike protein, leading to immune evasion from many therapeutic neutralizing antibodies. Therefore, it is of immense clinical significance to develop a potent neutralizing antibody against the Omicron variant.On March 28, 2022, Prof. ZHU Yongqun at ...
3D glasses in operating theatre reduce surgery risks
2
2522494
/english/2022/0422/c65147a2522494/page.psp
2022-04-22
static/picture/683f8631-9a34-4fa4-8b69-5eebc54d9ffb_s.jpg
static/picture/683f8631-9a34-4fa4-8b69-5eebc54d9ffb.jpg
You might get used to the 3D glasses in the movie theatre, but have you seen an ophthalmologist wearing 3D glasses and staring at the screen in the operating theatre?On March 24, two combined cataract and vitreoretinal surgeries were conducted by Prof. FANG Xiaoyun with the help of NCvideoHD, a three-dimensional high-definition visualization system, at the Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine (SAHZU).The success of the surgeries not only indicates ...
Scientists uncover a new tumor cells-fibroblasts juxtacrine signaling that promotes gastric cancer metastasis
3
2520434
/english/2022/0418/c65147a2520434/page.psp
2022-04-19
static/picture/9eb9a137-0fe5-44d6-992f-fc11c2607e98_s.png
static/picture/9eb9a137-0fe5-44d6-992f-fc11c2607e98.png
The interaction between tumor cells and cells in the microenvironment is crucial for tumor metastasis. At present, there is an in-depth understanding of paracrine signaling-mediated cell-to-cell interactions in the tumor microenvironment and its role in tumor metastasis. For example, during the progression of gastric cancer, a variety of cytokines, growth factors and extracellular matrix proteins have been reported to promote the progression and metastasis of tumor cells. Clinically, we have not...
Precise treatment for children with spinal muscular atrophy
4
2506480
/english/2022/0314/c65147a2506480/page.psp
2022-03-14
static/picture/3472cdc3-6975-4282-8286-b398004345d7_s.jpg
static/picture/3472cdc3-6975-4282-8286-b398004345d7.jpg
“There are no heroes who fall from the sky. Thanks to the medical team of the Children’s Hospital, Zhejiang University School of Medicine (ZUCH)!” Congcong’s mother shared this message on the Wechat to express her gratitude on the 15th International Rare Disease Day after her son successfully received the ultrasound-guided intrathecal injection of Nusinersen, the first disease-modifying therapy for Spinal Muscular Atrophy (SMA). Congcong has suffered from SMA for 13 years. With no medic...
ZJU scientists develop “musical dish” to induce osteogenic differentiation through music derived microstretch with variable frequency
5
2503482
/english/2022/0306/c65147a2503482/page.psp
2022-03-06
static/picture/55cf903c-cb14-4887-90f2-b2b55a164ce9_s.png
static/picture/55cf903c-cb14-4887-90f2-b2b55a164ce9.png
Stretch, as a form of mechanical force, plays a crucial role in regulating cell behaviors, preventing injuries and repairing tissues such as lung, heart, brain and skeletal system. Among them, stretch in bone tissues has captured the most immense attention in clinical applications, for bone tissues are continuously exposed to stretch stimulation during physiological activities. The structure and function of bone tissues relies on a proper amount of stretch stimulation, while lack of exercises te...
ZJU scientists elucidate novel molecular mechanism of MYBPC3-related hypertrophic cardiomyopathy using human iPSC-CM model
6
2500359
/english/2022/0224/c65147a2500359/page.psp
2022-02-25
static/picture/4de9ca2c-3783-4d66-bda0-1911b131ca4c_s.jpg
static/picture/4de9ca2c-3783-4d66-bda0-1911b131ca4c.jpg
Hypertrophic cardiomyopathy (HCM), characterized by left ventricular hypertrophy and fibrosis, is the most common monogenic cardiovascular disorder with global distribution and diverse clinical spectrum. The disease prevalence has been estimated at approximately 1:500 in the general population and even higher (1 case per 200) when both clinical and genetic diagnoses are taken into accounts. Patients with HCM are predisposed to heart failure, outflow tract obstruction and arrhythmias. The most vi...
Licensing but not fueling: a metabolic enzyme promotes mitosis beyond metabolism
7
2499587
/english/2022/0223/c65147a2499587/page.psp
2022-02-23
static/picture/2c27e3b8-67a2-4138-80dd-b502541a549d_s.jpg
static/picture/2c27e3b8-67a2-4138-80dd-b502541a549d.jpg
Uncontrolled cell proliferation is a hallmark of cancer. To sustain the ceaseless cell division, cancer cells rewire metabolic pathways in order to provide sufficient nutrient and energy for mitotic progression. Metabolic reprogramming of cancer cells is usually orchestrated by dysregulation of metabolic enzymes. It is generally thought that dysregulated metabolic enzymes contribute to cell cycle progression mainly by providing essential metabolites to meet the cellular needs for biosynthesis an...
Therapeutic potential of opioid agonists in human leukemia
8
2499427
/english/2022/0222/c65147a2499427/page.psp
2022-02-22
static/picture/d74cbeeb-eb27-49f8-a9a7-ff54f344564f_s.png
static/picture/d74cbeeb-eb27-49f8-a9a7-ff54f344564f.png
Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately, during the past a few decades, the first-line leukemia therapy has long been traditional chemotherapy with high cytotoxicity and low selectivity, such as the “7+3” strategy, i.e., a combination of cytarabine and doxorubicin. Also, side effects of such intensive chemotherapies are often severe, especially in elder patients. Therefore, it is in urgent need...
Unraveling correlation of Cd induced metabolic toxicity and diabetes
9
2498069
/english/2022/0217/c65147a2498069/page.psp
2022-02-17
static/picture/417ca509-5a35-4688-9ec8-c04d9c954634_s.png
static/picture/417ca509-5a35-4688-9ec8-c04d9c954634.png
Diabetes has become the leading metabolic disease threatening human health. Meanwhile, the association between exposure to harmful environmental factors and the occurrence of diabetes has always been a hot spot of public health and environmental medicine.A recent study conducted by Dr. ZHOU Zhou’s lab at the Department of Environmental Medicine, the Zhejiang University School of Medicine elucidated the Cd perturbed metabolomic signature in pancreatic beta cells and human urine. The origina...
Optimization of metabolomic data processing using machine learning and parallel computing
10
2496795
/english/2022/0126/c65147a2496795/page.psp
2022-01-26
static/picture/6d727b9e-afd7-49a1-ae0c-4302ccd3ea8b_s.png
static/picture/6d727b9e-afd7-49a1-ae0c-4302ccd3ea8b.png
Metabolomics involves the qualitative and quantitative analysis of the unique chemical fingerprints that specific physiological and pathological processes leave behind. Due to its uniqueness of closely linking to the phenotypes, metabolomics is applied to a variety of stages in drug discovery (such as drug target identification, lead compound discovery, drug metabolism analysis, drug response and resistance), and expected to significantly accelerate the development of new drug. However, the succ...