Myocardial hypertrophy, characterized by an increase in cardiac muscle mass, is an adaptive response to pathological stimuli such as hypertension and valve disease. While initially beneficial, sustained hypertrophy may lead to further disease progression and exacerbate heart failure, which is one of the most common and deadly medical conditions worldwide and remains incurable. Inhibition or reversal of cardiac hypertrophy and subsequent maladaptive myocardial remodeling is the main treatments fo...